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KMID : 0043320130360121516
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Archives of Pharmacal Research
2013 Volume.36 No. 12 p.1516 ~ p.1524
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Chemical constituents from Inula wissmanniana and their anti-inflammatory activities
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Wang Chunhui
Zhang Xufeng
Wei Panlei
Cheng Xiangrong
Ren Jie
Yan Shikai
Zhang Weidong
Jin Huizi
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Abstract
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Two new inositol derivatives, 4-acetate-1,2,3,5-tetrakis(2-methyl-2-butenoate) inositol (1) and 3-acetate-1,2,4,5-tetrakis(2-methyl-2-butenoate) inositol (2), one new flavonolignan 23-o-acetylsilychristin A (3), and one new thymol derivative 3-hydroxy-4-(2-hydroxy-1-methylethyl)benzoic acid (4), along with 13 known compounds, including ten flavonolignans (5?14) and three thymol derivatives (15?17) were isolated from the aerial part of Inula wissmanniana. The structures of new compounds were elucidated by detailed spectroscopic analysis, including HRESIMS and 2D-NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The anti-inflammatory activities of the compounds were tested against LPS-induced NO production in RAW 264.7 macrophages.
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KEYWORD
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Inula wissmanniana, Inositol derivatives, Flavonolignans, Thymol derivatives, Anti-inflammatory
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